Selected as a Doody's Core Title for 2022!
Covers clinical research in its many forms, including clinical trials, observational studies, translational science, and patient-oriented research.
Presents epidemiologic terms and principles and advanced conceptual material in a practical and reader-friendly manner.
Discusses key changes in the field, including confounding and directed acyclic graphs, surrogate outcomes and biomarkers, instrumental variables and Mendelian randomization, regression discontinuity designs, alternative data sources, AI and machine learning, pilot studies, as well as an update on P values and Bayesian analysis..
Covers modifications of classic randomized trials, such as pre/post, interrupted time series, difference-in-differences, stepped wedge and cluster randomized designs, as well as randomized trials in health systems.
Adds new chapters on qualitative approaches to clinical research and on community-engaged research
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