1The core content difference between this Fourth and the Third Edition is minimal. In addition to the correction of the typos found in the Third Edition, this Fourth Edition has made minor refinements but updated substantially the status and the discussion of numerous contemporary issues covered in this book. In particular, this Fourth Edition has highlighted a number of recent public health and regulatory concerns, including the global concerns with the recent pandemics of Zika as well as Ebola and the U.S. Food and Drug Administration