Chance, our not-so-quiet church mouse, is at it again, creating havoc with his best pal, Buddy. His favorite foil, Minister Marvin, hires the scariest exterminator in town to eliminate the church's pests, putting Chance and his tight-knit rodent family and friends in danger. Do they have a praying "Chance"? Will Chance come up with a plan of action? Or does the ensuing adventure needed to defeat the exterminator call for the perfect blend of both?