400 years ago, a single event sparked a long-simmering feud between John and Renphor. Now, the two vampires' lives will become impossibly intertwined in modern-day Philadelphia, leading to a final showdown. As the two try to adapt to a quickly changing world, everyone around them will get swept up in their schemes.

The feud will only end when one of them is destroyed - but as they lose the support of friends and lovers, which one will successfully navigate a world where everyone is lying?