7Epidemiology of Total Hip and Knee Arthroplasty Infection.- Risk Factors for Periprosthetic Joint Infection.- Prevention of Periprosthetic Joint Infection.- Medical Optimalization of Patients Prior to Surgery.- Diagnosis of Periprosthetic Joint Infection: An Algorithmic Approach to Patients.- Intraoperative Tests to Aid in Diagnosis of Periprosthetic Joint Infection.- Biofilm-Related Periprosthetic Joint Infection.- Microbiology of Periprosthetic Joint Infection.- Antibiotics in Treatment of Periprosthetic Joint Infection.- PMMA and Antimicrobial Delivery.- Prosthetic Retention: Treatment Options.- Single-Stage Exchange for Treatment of Periprosthetic Joint Infection.- Two-Stage Exchange Hip Arthroplasty: Static Spacers.- Two-Stage Exchange Hip Arthroplasty: Articulating Spacers.- Two-Stage Exchange Knee Arthroplasty: Static Spacers.- Two-Stage Exchange Knee Arthroplasty: Articulating Spacers.- Knee Arthrodesis.- Resection Arthroplasty and Hip Joint Fusion.- Above-Knee Amputation.- Post-Operative Management of Periprosthetic Joint Infection.