It's 1893, and wandering cowboy brothers Big Red and Old Red Amlingmeyer are down to their last few pennies. When a job becomes available at a ranch run by a confident and enigmatic foreman, neither brother can say no.

Although the work is tiresome and their boss is bad-tempered, they have a welcome distraction-the Sherlock Holmes stories Old Red has come to love so much.

But when someone discovers a dead body on the ranch, a menacing game is afoot. Old Red is determined to catch the killer using Holmes' infamous methods, and Big Red is dragged along for the wild ride-whether he likes it or not-while his brother tries to deduce his way to the truth.

Can Old Red and Big Red solve the mystery with stampedes, rustlers, Holmes-hating aristocrats, and a cannibal named Hungry Bob standing in their way?